NLRX1 Antibody (YA7946)
(Synonyms: CLR11.3; DLNB26; NOD5; NOD9; NOD26)NLRX1 Antibody (YA7946) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NLRX1.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
NLRX1 Antibody (YA7946) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NLRX1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
Human recombinant protein fragment corresponding to amino acids 866-975 of human NLRX1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NLRX1 participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species. Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases[1][2][3][4].
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Subcellular Localization
Mitochondrion outer membrane
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Expression
Tissue_Specificity: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level) -
Isoforms & Post-Translational Modification
Q86UT6 has two isomers: Q86UT6-1: 107616 Da (predicted); Q86UT6-2: 101876 Da (predicted).
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Subunit
Homohexamer (PubMed:22386589)
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SwissProt ID
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Synonyms
CLR11.3; DLNB26; NOD5; NOD9; NOD26
Documentation
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