NLRX1 Antibody (YA7946)

Art. -Nr.: HY-P88262: Data Sheet User Guide for Antibodies
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NLRX1 Antibody (YA7946) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NLRX1.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Größe	Preis	Verfügbarkeit
20 μL		Anfrage über Preis & Lieferzeit
50 μL		Anfrage über Preis & Lieferzeit
100 μL		Anfrage über Preis & Lieferzeit

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung
Verweise

Beschreibung

NLRX1 Antibody (YA7946) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NLRX1.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q86UT6

Immunogen

Human recombinant protein fragment corresponding to amino acids 866-975 of human NLRX1 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Reinheit	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2b

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity)

Subcellular Localization：Mitochondrion outer membrane

Expression：
Tissue_Specificity: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level)

Isoforms & Post-Translational Modification：Q86UT6 has two isomers: Q86UT6-1: 107616 Da (predicted); Q86UT6-2: 101876 Da (predicted).

Subunit：Homohexamer (PubMed:22386589)

Synonyms

CLR11.3; DLNB26; NOD5; NOD9; NOD26

Dokumentation

User Guide for Antibodies (1077 KB)

Verweise

[1]. /biology-dictionary/pc-3-cell.html [Content Brief]