NM23A Antibody (YA1002)
(Synonyms: NME1; NDPKA; NM23; Nucleoside diphosphate kinase A; NDK A; NDP kinase A; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; Tumor metastatic process-associated protein; nm23-H1)NM23A Antibody (YA1002) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NM23A.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
NM23A Antibody (YA1002) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NM23A.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 16,18 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 17 kDa
Entrez Gene: 4830 Human ; 18102 Mouse ; 191575 Rat
SwissProt: P15531 Human ; P15532 Mouse ; Q05982 Rat
OMIM: 156490 Human
Synthetic peptide corresponding to human NME1/NDKA protein
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_specificity:Isomer 1 is expressed in the heart, brain, placenta, lungs, liver, skeletal muscle, pancreas, spleen, and thymus. It is expressed in lung cancer cell lines but not in normal lung tissue. Isomer 2 is universally expressed, and its expression is also associated with tumor differentiation. -
Isoforms & Post-Translational Modification
P15531 has 3 isomers: P15531-1: 17149 Da (predicted); P15531-2: 19654 Da (predicted); P22392-2: 30137 Da (predicted).
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Subunit
Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with PRUNE1. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1.
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SwissProt ID
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Synonyms
NME1; NDPKA; NM23; Nucleoside diphosphate kinase A; NDK A; NDP kinase A; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; Tumor metastatic process-associated protein; nm23-H1
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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