NME1 - NME/NM23 nucleoside diphosphate kinase 1 Gene
Also Known as NB; AWD; NBS; GAAD; NDKA; NM23; NDPKA; NDPK-A; NM23-H1
Species: Homo sapiens
About NME1
This gene has 10 transcripts (splice variants), 146 orthologues and 8 paralogues. Ubiquitous expression in appendix (RPKM 37.1), brain (RPKM 32.2) and 25 other tissues.
Summary
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
NME1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_000269.3 | NP_000260.1 | nucleoside diphosphate kinase A isoform b |
| NM_198175.1 | NP_937818.1 | nucleoside diphosphate kinase A isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables 3'-5' exonuclease activity |
IDA
IDA: Inferred from direct assay
|
14960567 | GOA |
| enables ATP binding |
IDA
IDA: Inferred from direct assay
|
12972261 | GOA |
| enables DNA nuclease activity |
IDA
IDA: Inferred from direct assay
|
11555662 | GOA |
| enables GTP binding |
IDA
IDA: Inferred from direct assay
|
12972261 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
10602478 | GOA |
| enables magnesium ion binding |
IDA
IDA: Inferred from direct assay
|
11555662 | GOA |
| enables nucleoside diphosphate kinase activity |
IDA
IDA: Inferred from direct assay
|
9488696 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10602478 | GOA |
| enables ribosomal small subunit binding |
IPI
IPI: Inferred from physical interaction
|
16814409 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of DNA binding |
IDA
IDA: Inferred from direct assay
|
17975005 | GOA |
| involved in positive regulation of epithelial cell proliferation |
IMP
IMP: Inferred from mutant phenotype
|
16862176 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
16814409 | GOA |
| located in early endosome |
IDA
IDA: Inferred from direct assay
|
37267906 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
16313181 | GOA |
| located in ruffle membrane |
IDA
IDA: Inferred from direct assay
|
16814409 | GOA |
NME1 Protein Structure
NDK: Nucleoside diphosphate kinase (5 - 138)
- 0
- 100
- 152 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
nucleoside diphosphate kinase A |
|
NME1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
NME1 | P15531 | PID1 | Homo sapiens | Q7Z2X4 | 25416956 | |
|
Intra
|
NME1 | P15531 | SREK1IP1 | Homo sapiens | Q8N9Q2 | 25416956 | |
|
Intra
|
NME1 | P15531 | TNPO3 | Homo sapiens | Q9Y5L0 | 32296183 | |
|
Intra
|
NME1 | P15531 | POLR1C | Homo sapiens | O15160 | 25416956 | |
|
Intra
|
NME1 | P15531 | POLR1C | Homo sapiens | O15160 | 21988832 | |
|
Intra
|
NME1 | P15531 | POLR1C | Homo sapiens | O15160 | 16189514 | |
|
Cross
|
NME1 | P15531 | Ksr1 | Mus musculus | Q61097 | 15684389 | |
|
Intra
|
NME1 | P15531 | P10911-PRO_0000030434 | Homo sapiens | P10911-PRO_0000030434 | 18470881 | |
|
Intra
|
NME1 | P15531 | P10911-PRO_0000030434 | Homo sapiens | P10911-PRO_0000030434 | 18470881 | |
|
Intra
|
NME1 | P15531 | P10911-PRO_0000030434 | Homo sapiens | P10911-PRO_0000030434 | 18470881 | |
|
Intra
|
NME1 | P15531 | P10911-PRO_0000030434 | Homo sapiens | P10911-PRO_0000030434 | 18470881 | |
|
Intra
|
NME1 | P15531 | PRUNE1 | Homo sapiens | Q86TP1 | 10602478 | |
|
Intra
|
NME1 | P15531 | TNPO2 | Homo sapiens | O14787 | 25416956 | |
|
Intra
|
NME1 | P15531 | NUTF2 | Homo sapiens | P61970 | 32296183 | |
|
Intra
|
NME1 | P15531 | NME3 | Homo sapiens | Q13232 | 16189514 | |
|
Intra
|
NME1 | P15531 | NME3 | Homo sapiens | Q13232 | 25416956 | |
|
Intra
|
NME1 | P15531 | NME3 | Homo sapiens | Q13232 | 25416956 | |
|
Intra
|
NME1 | P15531 | NME3 | Homo sapiens | Q13232 | 25416956 | |
|
Intra
|
NME1 | P15531 | NME2 | Homo sapiens | P22392 | 21988832 | |
|
Intra
|
NME1 | P15531 | NME2 | Homo sapiens | P22392 | 31980649 | |
|
Intra
|
NME1 | P15531 | NME2 | Homo sapiens | P22392 | 33961781 | |
|
Intra
|
NME1 | P15531 | STRAP | Homo sapiens | Q9Y3F4 | 17314099 | |
|
Intra
|
NME1 | P15531 | STRAP | Homo sapiens | Q9Y3F4 | 17314099 | |
|
Intra
|
NME1 | P15531 | STRAP | Homo sapiens | Q9Y3F4 | 17314099 | |
|
Intra
|
NME1 | P15531 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
NME1 | P15531 | FXR2 | Homo sapiens | P51116 | 19060904 | |
|
Intra
|
NME1 | P15531 | FXR2 | Homo sapiens | P51116 | 21653829 | |
|
Intra
|
NME1 | P15531 | FXR2 | Homo sapiens | P51116 | 19060904 | |
|
Intra
|
NME1 | P15531 | NME4 | Homo sapiens | O00746 | 16189514 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 17314099 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 32296183 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 32296183 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 10602478 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 25910212 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 31515488 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 16189514 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 25910212 | |
|
Intra
|
NME1 | P15531 | NME4 | Homo sapiens | O00746 | 25416956 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 25502805 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 25910212 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 17314099 | |
|
Intra
|
NME1 | P15531 | NME4 | Homo sapiens | O00746 | 33961781 | |
|
Intra
|
NME1 | P15531 | NME4 | Homo sapiens | O00746 | 25416956 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 25416956 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 32296183 | |
|
Intra
|
NME1 | P15531 | NME1 | Homo sapiens | P15531 | 25416956 | |
|
Intra
|
NME1 | P15531 | NTAQ1 | Homo sapiens | Q96HA8 | 31515488 | |
|
Intra
|
NME1 | P15531 | NTAQ1 | Homo sapiens | Q96HA8 | 19060904 | |
|
Intra
|
NME1 | P15531 | NTAQ1 | Homo sapiens | Q96HA8 | 32296183 | |
|
Intra
|
NME1 | P15531 | NTAQ1 | Homo sapiens | Q96HA8 | 19060904 | |
|
Intra
|
NME1 | P15531 | NTAQ1 | Homo sapiens | Q96HA8 | 16189514 |
Recombinant NME1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70299 | NME1/NDPKA Protein, Human (His) | P15531-1 (M1-E152) | ≥ 90%, as determined by reducing SDS-PAGE. |
NME1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81289 | NM23A Antibody (YA1002) | WB | Human, Mouse, Rat |
| HY-P81289A | NM23A Antibody (YA1003) | WB | Human |
| HY-P81289AA | NM23A Antibody (YA1003)(PBS only) | WB | Human |
| HY-P85299 | NM23A Antibody (YA4991) | WB, IHC-P, IHC-F, IF-Tissue | Human, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Lung Large Cell Carcinoma |
|
|
| Larynx Cancer |
|
|
| Peripheral T-Cell Lymphoma |
|
|
| Hypopharynx Cancer |
|
|
| Breast Ductal Carcinoma |
|
|
| Neuroblastoma |
|
|
| Laryngeal Squamous Cell Carcinoma |
|
|
| Papillary Carcinoma |
|
|
| Cervical Intraepithelial Neoplasia |
|
|
| Colorectal Cancer |
|
|
| Seminoma |
|
|
| Anal Canal Carcinoma |
|
|
| Breast Cancer |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Ovarian Cancer |
|
|
| Breast Fibroadenoma |
|
|
| Leukemia, Acute Monocytic |
|
|
| Squamous Cell Carcinoma |
|
|
| Transitional Cell Carcinoma |
|
|
| Lung Cancer |
|
|
| Gallbladder Cancer |
|
|
| Gastric Cancer |
|
|
| Mouth Disease |
|
|
| Cervical Adenocarcinoma |
|
|
| Follicular Adenoma |
|
|
| Atrial Tachyarrhythmia With Short Pr Interval |
|
|
| Malignant Hyperthermia |
|
|
| Papillary Adenocarcinoma |
|
|
| Endometrial Cancer |
|
|
| Adenosquamous Carcinoma |
|
|
| Thyroid Gland Cancer |
|
|
| Nodular Tenosynovitis |
|
|
| Skin Melanoma |
|
|
| Melanoma |
|
|
| Burkitt Lymphoma |
|
|
| Cervical Cancer |
|
|
| Nemaline Myopathy 2 |
|
|
| Hepatocellular Carcinoma |
|
|
| Bladder Cancer |
|
|
| Melanoma, Uveal |
|
|
| Pheochromocytoma |
|
|
| Prostate Cancer |
|
|
| Esophageal Cancer |
|
|
| Leukemia, Chronic Myeloid |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | NME1 | RGD | RGD:70497 |
| Mus musculus | NME1 | MGD | MGI:97355 |
| Others | NME1 | NCBI |