Ksr1 - kinase suppressor of ras 1 Gene

Also Known as hb; Ksr; RSU2; mKSR1; B-KSR1; D11Bhm183e; D11Bhm184e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16706

Summary

Enables several functions, including 14-3-3 protein binding activity; ATP binding activity; and HSP90 protein binding activity. Involved in intracellular signal transduction; regulation of MAP kinase activity; and regulation of cell population proliferation. Acts upstream of or within positive regulation of MAPK cascade. Predicted to be located in cell projection and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human KSR1 (kinase suppressor of Ras 1). [provided by Alliance of Genome Resources, Apr 2022]

Ksr1 Products (2)

mRNA	Protein	Name
NM_001348207.1	NP_001335136.1	kinase suppressor of Ras 1 isoform 2
NM_013571.3	NP_038599.1	kinase suppressor of Ras 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 14-3-3 protein binding	IPI IPI: Inferred from physical interaction	10409742	MGI
enables ATP binding	IMP IMP: Inferred from mutant phenotype	21441104	MGI
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	10409742	MGI
enables MAP-kinase scaffold activity	IDA IDA: Inferred from direct assay	19560418	MGI
enables MAP-kinase scaffold activity	IMP IMP: Inferred from mutant phenotype	10409742	MGI
enables mitogen-activated protein kinase kinase binding	IPI IPI: Inferred from physical interaction	10409742	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12941695	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	21441104	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21441104	MGI
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	10409742	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	21102438	MGI
involved in cAMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	21102438	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	19560418	MGI
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	10409742	MGI
involved in regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	12874031	MGI
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12874031	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
kinase suppressor of Ras 1	protein Hb

Ksr1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Ksr1	Q61097	VRK2	Homo sapiens	Q86Y07-1	Pull Down	22752157
Cross	Ksr1	Q61097	NME1	Homo sapiens	P15531	Anti Tag CoIP	15684389
Cross	Ksr1	Q61097	NME1	Homo sapiens	P15531	Anti Bait CoIP	15684389
Intra	Ksr1	Q61097	Arhgef2	Mus musculus	Q60875	Anti Bait CoIP	24525234
Intra	Ksr1	Q61097	Arhgef2	Mus musculus	Q60875	CoIP	24525234
Intra	Ksr1	Q61097	Arhgef2	Mus musculus	Q60875	Anti Tag CoIP	24525234

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07475	KSR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19611	Ksr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26106	Ksr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ksr1	NCBI	NCBI:8844