Arhgef2 - rho/rac guanine nucleotide exchange factor (GEF) 2 Gene

Also Known as GEF; Lfc; P40; GEFH1; LFP40; Lbcl1; GEF-H1; mKIAA0651

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16800

Summary

Enables guanyl-nucleotide exchange factor activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; generation of neurons; and positive regulation of neuron migration. Acts upstream of or within several processes, including actin filament organization; negative regulation of podosome assembly; and regulation of Rho protein signal transduction. Located in several cellular components, including dendritic shaft; podosome; and postsynaptic density. Is expressed in several structures, including brain; dorsal root ganglion; and testis. Used to study neurodevelopmental disorder with midbrain and hindbrain malformations. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef2 Products (5)

mRNA	Protein	Name
NM_001198911.2	NP_001185840.1	rho guanine nucleotide exchange factor 2 isoform 2
NM_001198912.2	NP_001185841.1	rho guanine nucleotide exchange factor 2 isoform 3
NM_001198913.2	NP_001185842.1	rho guanine nucleotide exchange factor 2 isoform 4
NM_001377126.1	NP_001364055.1	rho guanine nucleotide exchange factor 2 isoform 5
NM_008487.4	NP_032513.3	rho guanine nucleotide exchange factor 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	15996550	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	15996550	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15996550	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within actin filament organization	IPI IPI: Inferred from physical interaction	15996550	MGI
involved in asymmetric neuroblast division	IMP IMP: Inferred from mutant phenotype	28453519	MGI
acts upstream of or within cell morphogenesis	IDA IDA: Inferred from direct assay	15996550	MGI
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	19448628	MGI
involved in negative regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	19448628	MGI
acts upstream of or within negative regulation of podosome assembly	IMP IMP: Inferred from mutant phenotype	21352810	MGI
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	28453519	MGI
involved in positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	28453519	MGI
acts upstream of or within regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	15996550	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in dendritic shaft	IDA IDA: Inferred from direct assay	15996550	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	15996550	MGI
located in podosome	IDA IDA: Inferred from direct assay	21352810	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
rho guanine nucleotide exchange factor 2	LBC'S first cousin guanine nucleotide exchange factor H1 lymphoid blast crisis-like 1 oncogene LFC rhobin

Arhgef2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Arhgef2	Q60875	Ksr1	Mus musculus	Q61097	Anti Tag CoIP	24525234
Intra	Arhgef2	Q60875	Ksr1	Mus musculus	Q61097	Anti Bait CoIP	24525234
Intra	Arhgef2	Q60875	Ccdc88b	Mus musculus	Q4QRL3	IF	38200184
Intra	Arhgef2	Q60875	Ccdc88b	Mus musculus	Q4QRL3	Anti Bait CoIP	38200184
Intra	Arhgef2	Q60875	Ccdc88b	Mus musculus	Q4QRL3	Anti Tag CoIP	38200184

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00954	ARHGEF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arhgef2	NCBI	NCBI:9181