NME3 - NME/NM23 nucleoside diphosphate kinase 3 Gene

Also Known as NDPKC; NDPK-C; NM23H3; DR-nm23; NM23-H3; c371H6.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4832

About NME3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,770,320-1,771,543 (from NCBI)

This gene has 11 transcripts (splice variants), 177 orthologues and 8 paralogues. Ubiquitous expression in prostate (RPKM 24.8), fat (RPKM 18.6) and 25 other tissues.

Summary

Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in apoptotic process and nucleotide metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

NME3 Products (1)

mRNA Protein Name
NM_002513.3 NP_002504.2 nucleoside diphosphate kinase 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nucleoside diphosphate kinase activity IDA
IDA: Inferred from direct assay
30587587 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA repair IMP
IMP: Inferred from mutant phenotype
26945015 GOA
involved in mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
30587587 GOA
involved in nucleoside triphosphate biosynthetic process IDA
IDA: Inferred from direct assay
30587587 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26945015 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
30587587 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NME3 Protein Structure

NDK

NDK: Nucleoside diphosphate kinase (22 - 155)

  • 0
  • 100
  • 169 a.a.
Protein Preferred Names Protein Names

nucleoside diphosphate kinase 3

  • NDK 3

NME3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NME3 Q13232 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
NME3 Q13232 DESI1 Homo sapiens Q6ICB0
Validated Y2H
32296183
Intra
NME3 Q13232 DESI1 Homo sapiens Q6ICB0
Y2H Prey Pooling
32296183
Intra
NME3 Q13232 DESI1 Homo sapiens Q6ICB0
Y2H Array
32296183
Intra
NME3 Q13232 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
NME3 Q13232 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
Intra
NME3 Q13232 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
NME3 Q13232 SGTA Homo sapiens O43765
Validated Y2H
25416956
Intra
NME3 Q13232 SGTA Homo sapiens O43765
Y2H Pooling
16189514
Intra
NME3 Q13232 NME2 Homo sapiens P22392
Anti Tag CoIP
33961781
Intra
NME3 Q13232 NME2 Homo sapiens P22392
Y2H Pooling
16169070
Intra
NME3 Q13232 NME1 Homo sapiens P15531
Anti Tag CoIP
33961781
Intra
NME3 Q13232 NME1 Homo sapiens P15531
Y2H Array
31515488
Intra
NME3 Q13232 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
NME3 Q13232 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
NME3 Q13232 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
NME3 Q13232 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
NME3 Q13232 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
NME3 Q13232 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
NME3 Q13232 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
NME3 Q13232 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
NME3 Q13232 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

NME3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83365 NME3 Antibody (YA3110) WB, IHC-P, IP Human
HY-P83365A NME3 Antibody (YA3110)(PBS only) WB, IHC-P, IP Human

Related Diseases

Diseases Alias
Lipase Deficiency, Combined

  • Lipoprotein Lipase Deficiency With Hepatic Triglyceride Lipase Deficiency

  • Lpl And Htgl Deficiency

  • Lpl And Hl Deficiency

  • Familial Lipase Maturation Factor 1 Deficiency

  • Lipase Deficiency Combined

  • Combined Lipase Deficiency

  • Familial Lmf1 Deficiency

  • CLD
Heinz Body Anemias

  • Heinz Body Anemia

  • Heinz Body Anemias, Alpha-

  • HEIBAN

  • Anemia, Heinz Body

  • Acquired Heinz Body Anemia
Zellweger Syndrome

  • Cerebrohepatorenal Syndrome

  • Zellweger Leukodystrophy

  • Zs

  • Congenital Iron Overload

  • Chr

  • Zws

  • Severe Pbd-Zsd

  • Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09374 NME3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20783 Nme3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27297 Nme3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NME3 VGNC VGNC:32126
Felis catus NME3 VGNC VGNC:107766
Macaca mulatta NME3 VGNC VGNC:75357
Rattus norvegicus NME3 RGD RGD:619879
Mus musculus NME3 MGD MGI:1930182
Canis familiaris NME3 VGNC VGNC:54050
Others NME3 NCBI