NME3 Antibody (YA3110)(PBS only)
(Synonyms: NDPKC; NDPK-C; NM23H3; DR-nm23; NM23-H3; c371H6.2)NME3 Antibody (YA3110) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NME3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IP
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:20 |
Product Details
NME3 Antibody (YA3110) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NME3.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 19 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 19 kDa
A synthetic peptide of human NME3 aa61-74.
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NME3 catalyzes the phosphorylation of ribonucleosides and deoxyribonucleoside diphosphates, other than ATP, into the corresponding triphosphates with ATP as the major phosphate donor. The ATP gamma phosphate is transferred to the nucleoside diphosphate beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Inhibits granulocyte differentiation. May be required for ciliary function during renal development; Independently of its kinase activity, facilitates mitochondrial tethering prior to membrane fusion through its direct membrane-binding and hexamerization. Implicated in repair of both single- and double-stranded breaks in DNA through its association with the ribonucleotide reductase complex (RNR complex) via its interaction with the histone acetyltransferase KAT5, this interaction enables recruitment of NME3 at DNA damage sites where it plays a role in the repair of DNA, independently of its kinase activity[1][2][3][4].
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Subcellular Localization
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasm; Cytoplasm, cytoskeleton, cilium basal body
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Subunit
Homohexamer (PubMed:30587587). Interacts (via its N-terminal region) with KAT5; this interaction enables recruitment of NME3 at DNA damage sites where it plays a role in the repair of DNA (PubMed:26945015). Found in association with several ciliary nephronophthisis proteins, including NEK8, CEP164, ANKS6 (PubMed:30111592)
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SwissProt ID
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Synonyms
NDPKC; NDPK-C; NM23H3; DR-nm23; NM23-H3; c371H6.2
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Research Field
Signal Transduction
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