NOTCH3 Antibody (YA7133)
(Synonyms: Neurogenic locus notch homolog protein 3, Notch 3, NOTCH3)NOTCH3 Antibody (YA7133) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to NOTCH3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS(pH 7.3), 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-2000 |
Product Details
NOTCH3 Antibody (YA7133) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to NOTCH3.
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Host Mouse
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 243 kD
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 255kDa
KLH conjugated synthetic peptide derived from human NOTCH3
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH 7.3), 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs[1].
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Subcellular Localization
Cell membrane,Nucleus
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Expression
Tissue_Specificity: Ubiquitously expressed in fetal and adult tissues -
Isoforms & Post-Translational Modification
Q9UM47: 2321 amino acids, molecular weight 243631 Da.
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Subunit
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity)
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SwissProt ID
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Synonyms
Neurogenic locus notch homolog protein 3, Notch 3, NOTCH3
Documentation
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