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NR2C1 Antibody (YA8696)(PBS only)

(Synonyms: TR2)

NR2C1 Antibody (YA8696) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NR2C1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • NR2C1 Antibody (YA8696)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:100-500

Product Details

Description

NR2C1 Antibody (YA8696) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NR2C1.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 51 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 1-237 of human NR2C1 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NR2C1 is an Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation

  • Subcellular Localization

    Nucleus,Nucleus, PML body

  • Isoforms & Post-Translational Modification

    P13056 has three isomers: P13056-1: 67315 Da (predicted); P13056-2: 51193 Da (predicted); P13056-3: 53042 Da (predicted).
    Sumoylation requires both PIAS1 and UBE2I丨Phosphorylated on several serine and threonine residues

  • Subunit

    Homodimer (By similarity)

  • SwissProt ID

    P13056

  • Synonyms

    TR2

NR2C1 Antibody (YA8696)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • NR2C1 Antibody (YA8696)(PBS only) Product Image