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NRBF2 Antibody (YA8703)(PBS only)

(Synonyms: COPR; COPR1; COPR2; NRBF-2)

NRBF2 Antibody (YA8703) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NRBF2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • NRBF2 Antibody (YA8703)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:100-500

Product Details

Description

NRBF2 Antibody (YA8703) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NRBF2.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
Immunogen

Full length human recombinant protein of human NRBF2 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NRBF2 may modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro)|Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation[1][2].

  • Subcellular Localization

    Nucleus,Cytoplasm,Cytoplasmic vesicle,Cytoplasmic vesicle, autophagosome

  • Expression


    Tissue_Specificity: Detected in keratinocytes, liver and placenta (PubMed:15610520). Expressed in a subset of cells in pediatric medulloblastoma (PubMed:18619852)

  • Isoforms & Post-Translational Modification

    Q96F24 has three isomers: Q96F24-1: 32378 Da (predicted); Q96F24-2: 26955 Da (predicted); Q96F24-3: 31001 Da (predicted).

  • Subunit

    Interacts with PPARA, PPARD and PPARG

  • SwissProt ID

    Q96F24

  • Synonyms

    COPR; COPR1; COPR2; NRBF-2

NRBF2 Antibody (YA8703)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • NRBF2 Antibody (YA8703)(PBS only) Product Image