Nur77 Antibody (YA7314)
Nur77 Antibody (YA7314) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nur77.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, IF-Tissue
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Formulation:
Supplied in 1*tris buffered saline (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.02% Proclin300.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:50-1000 | 1:50-1000 | 1:50-1000 |
Product Details
Nur77 Antibody (YA7314) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nur77.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Calculated Molecular Weight 0
KLH conjugated synthetic peptide derived from human Nur77
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*tris buffered saline (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.02% Proclin300.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nur77 is an Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter. May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration. Plays a role in the vascular response to injury|In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7[1][2][3][4][5].
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Subcellular Localization
Nucleus,Cytoplasm, cytosol,Mitochondrion
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Expression
Tissue_Specificity: Fetal muscle and adult liver, brain and thyroid
Induction: Induced by cytosporone B (Csn-B); directly stimulates its own expression (PubMed:18690216). Induced by corticotropin-releasing hormone (CRH) (PubMed:9315652). Induced by growth-stimulating agents (PubMed:1651101) -
Isoforms & Post-Translational Modification
P22736 has three isomers: P22736-1: 64463 Da (predicted); P22736-2: 65998 Da (predicted); P22736-3: 33754 Da (predicted).
Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli丨Acetylated by p300/CBP, acetylation increases stability -
Subunit
Binds the NGFI-B response element (NBRE) as a monomer (PubMed:18690216)
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SwissProt ID
Documentation
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