OAS2 Antibody (YA8040)
(Synonyms: MGC78578)OAS2 Antibody (YA8040) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to OAS2.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-4000 | 1:100-500 |
Product Details
OAS2 Antibody (YA8040) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to OAS2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 78.6 kDa
Human recombinant protein fragment corresponding to amino acids 60-335 of human OAS2 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
OAS2 is an Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates. Non-infected lobules would not be affected, allowing efficient pup feeding during infection[1][2][3][4].
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Subcellular Localization
Cytoplasm,Cytoplasm, perinuclear region
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Expression
Induction: By type I interferon (IFN) and viruses
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Isoforms & Post-Translational Modification
P29728 has three isomers: P29728-1: 82431 Da (predicted); P29728-2: 78787 Da (predicted); P29728-3: 19517 Da (predicted).
Myristoylation is not essential for its activity丨Glycosylated -
Subunit
Homodimer
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SwissProt ID
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Synonyms
MGC78578
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