OAS2 Antibody (YA8040)

Cat. No.: HY-P88356: Data Sheet User Guide for Antibodies
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OAS2 Antibody (YA8040) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to OAS2.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

OAS2 Antibody (YA8040) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to OAS2.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 78.6 kDa

Species Reactivity

Human

SwissProt ID

P29728

Immunogen

Human recombinant protein fragment corresponding to amino acids 60-335 of human OAS2 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2a

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:11682059, PubMed:9880569). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity)

Subcellular Localization：Cytoplasm,Cytoplasm, perinuclear region

Expression：Induction: By type I interferon (IFN) and viruses

Isoforms & Post-Translational Modification：P29728 has three isomers: P29728-1: 82431 Da (predicted); P29728-2: 78787 Da (predicted); P29728-3: 19517 Da (predicted).
Myristoylation is not essential for its activity丨Glycosylated

Subunit：Homodimer

Synonyms

MGC78578

Documentation

User Guide for Antibodies (1077 KB)