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Cat. No.: HY-P87759

ORP1 Antibody (YA7444)

ORP1 Antibody (YA7444) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to ORP1.

For research use only. We do not sell to patients.

Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:1000-1:5000	1:200-1:1000	1:5000-1:20000

Description

ORP1 Antibody (YA7444) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to ORP1.

Host Rabbit
Clonality Monoclonal,Recombinant
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 105 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 105 kDa

Immunogen

The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

Protein A affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG, Kappa

Appearance

Liquid
Formulation

Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

ORP1 binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol^[1]^[2].
Subcellular Localization

Late endosome
Isoforms & Post-Translational Modification

Q9BXW6 has three isomers: Q9BXW6-1: 108470 Da (predicted); Q9BXW6-2: 50253 Da (predicted); Q9BXW6-4: 65095 Da (predicted).
Subunit

Interacts (via FFAT motif) with VAPA and VAPB (PubMed:33124732)
SwissProt ID

Q9BXW6