ox-LDL Antibody (YA6405)

Cat. No.: HY-P86713: Data Sheet COA
SDS
User Guide for Antibodies
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ox-LDL Antibody (YA6405) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ox-LDL.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ox-LDL Antibody (YA6405) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ox-LDL.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 31 kDa

Species Reactivity

Human, Mouse, Rat

Gene ID

ox-LDL [NCBI]

Immunogen

Full length protein from human plasma

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1000
IHC-F IHC-F: Immunohistochemistry-Frozen	1:100-1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-1000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：ox-LDL is a receptor that mediates the recognition, internalization, and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. oxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, leading to pro-inflammatory responses, pro-oxidative conditions, and apoptosis. Its interaction with oxLDL triggers NF-kappa-B activation through increased intracellular reactive oxygen species production and various pro-atherogenic cellular responses, including reduced nitric oxide (NO) release, monocyte adhesion, and apoptosis. Beyond binding oxLDL, it functions as a receptor for HSP70 protein, facilitating antigen cross-presentation to naive T-cells in dendritic cells, thereby contributing to cell-mediated antigen cross-presentation. It also participates in inflammation by acting as a leukocyte-adhesion molecule at the vascular interface during endotoxin-induced inflammation. Additionally, it serves as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells, and both Gram-negative and Gram-positive bacteria. (Microbial infection) It may act as a receptor for Neisseria meningitidis adhesin A variant 3 (nadA).

Synonyms

ox-LDL: LDL(Copper oxidized); Cu2SO4 oxidized low density lipoprotein; oxidized low density lipoprotein; Low density lipoprotein; MDA oxidized LDL; MDA oxidized low density lipoprotein.

Documentation

Select Batch:

Data Sheet (230 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)