PDCL3 Antibody (YA8782)
(Synonyms: HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1)PDCL3 Antibody (YA8782) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDCL3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
PDCL3 Antibody (YA8782) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDCL3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 27.4 kDa
Full length human recombinant protein of human PDCL3 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PDCL3 acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis[1][2][3][4].
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Subcellular Localization
Cytoplasm,Cytoplasm, perinuclear region,Endoplasmic reticulum
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Expression
Tissue_Specificity: Expressed in endothelial cells (at protein level) (PubMed:26059764). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon (PubMed:15371430) -
Isoforms & Post-Translational Modification
Q9H2J4: 239 amino acids, molecular weight 27614 Da.
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Subunit
Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain) (PubMed:23792958, PubMed:26059764)
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SwissProt ID
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Synonyms
HTPHLP; PHLP2A; PHLP3; VIAF; VIAF1
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