PE-CF596-conjugated CD163 Antibody (MAC2-158)
(Synonyms: CD163,CD163-PE-CF596,MAC2-158)PE-CF596-conjugated CD163 Antibody (MAC2-158) is a Mouse-derived and PE-CF596 conjugated monoclonal antibody, targeting to CD163.
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Host:
Mouse
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Isotype:
Mouse IgG1,κ
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
PE-CF596
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD163 is a hemoglobin scavenger receptor primarily expressed on the surface of monocytes and macrophages; it functions by mediating the clearance of Hb-Hp complexes and inducing anti-inflammatory pathways. In immunological research, CD163 serves as a key marker for M2-like macrophages, tumor-associated macrophages (TAMs), and tissue-repair macrophages.
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Expression
Tissue_specificity:This protein is expressed in monocytes and mature macrophages, such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident macrophages in the bone marrow, and meningeal macrophages in the central nervous system. It is also expressed in the blood. Isotype 1 is present in the lowest concentration in the blood. Isotype 2 is present in the lowest concentrations in the liver and spleen. Isotype 3 is the predominant isotype detected in the blood.
Induction:Induced by anti-inflammatory mediators such as glucocorticoids, interleukin-6/IL6 and interleukin-10/IL10; suppressed by pro-inflammatory mediators like bacterial lipopolysaccharides (LPS) , IFNG/IFN-gamma and TNF -
Isoforms & Post-Translational Modification
CD163 has 4 isomers: Q86VB7-1: 125451 Da (predicted); Q86VB7-2: 125982 Da (predicted); Q86VB7-3: 121609 Da (predicted); Q86VB7-4: 124958 Da (predicted).
A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs;Phosphorylated -
Subunit
Interacts with CSNK2B
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Synonyms
CD163,CD163-PE-CF596,MAC2-158
Documentation
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