PE-CF596-conjugated CD33 Antibody (6C5)
(Synonyms: CD33,CD33-PE-CF596,6C5)PE-CF596-conjugated CD33 Antibody (6C5) is a Mouse-derived and PE-CF596 conjugated monoclonal antibody, targeting to CD33.
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Host:
Mouse
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Isotype:
Mouse IgG2a,κ/Mouse IgG1,κ
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
PE-CF596
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
PE-CF596-conjugated CD33 Antibody (6C5) is a Mouse-derived and PE-CF596 conjugated monoclonal antibody, targeting to CD33.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
PE-CF596
Unmodified
Mouse IgG2a,κ/Mouse IgG1,κ
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD33 (Siglec-3) is an important member of the sialic acid-binding immunoglobulin-like lectin family, one of the most classic surface markers of myeloid cells, and one of the most important targets in acute myeloid leukemia (AML). CD33 is an inhibitory immune receptor belonging to the immunoglobulin superfamily (IgSF), and its intracellular structure contains the immunoreceptor tyrosine inhibitory motif (ITIM).
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Peroxisome
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Expression
Tissue_specificity:Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells -
Isoforms & Post-Translational Modification
CD33 has 3 isomers: P20138-1: 39825 Da (predicted); P20138-2: 33890 Da (predicted); P20138-3: 25293 Da (predicted).
Glycosylated. Glycosylation at Asn-100 is critical for regulating ligand recognition;Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. LCK phosphorylates Tyr-340 efficiently and Tyr-358 to a lesser extent -
Subunit
Homodimer; disulfide-linked (PubMed:10887109). Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation (PubMed:10206955, PubMed:10556798).
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Synonyms
CD33,CD33-PE-CF596,6C5
Documentation
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