PE-conjugated CD20 Antibody (2H7)
(Synonyms: CD20,CD20-PE,2H7)PE-conjugated CD20 Antibody (2H7) is a Mouse-derived and PE conjugated monoclonal antibody, targeting to CD20.
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Host:
Mouse
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Isotype:
Mouse IgG2b,κ
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
PE
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD20 is a 33-37 kDa non-glycosylated protein expressed specifically on the surface of normal and malignant B lymphocytes, and belongs to the MS4A (membrane-spanning 4-domain family A) protein family. CD20 is a general B-cell marker expressed by the majority of B cells starting from late pre-B lymphocytes (it is not expressed by pro-B lymphocytes), and its expression is lost in terminally differentiated plasmablasts and plasma cells. Early experiments suggested that it was important in the regulation of human B-cell activation, proliferation, and Ca2+ transport. However, CD20-deficient mice appeared normal. Hence, the exact biological function of CD20 and its physiological ligand remain to be fully defined.240 Regardless of the uncertainty in the biological role of this antigen, it is a good target for cancer immunotherapy.
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Cell membrane; Lipid-anchor
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Expression
Tissue_specificity:Expressed on B cells -
Isoforms & Post-Translational Modification
CD20 has 2 isomers: P11836-1: 33077 Da (predicted); P11836-2: 14581 Da (predicted).
Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate -
Subunit
Forms homotetramers (PubMed:18474602, PubMed:7684739). Interacts with the heavy and light chains of cell surface IgM, the antigen-binding components of the BCR (PubMed:18474602)
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Synonyms
CD20,CD20-PE,2H7
Documentation
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