PE-conjugated CD28 Antibody (CD28.2)
(Synonyms: CD28,CD28-PE,CD28.2)PE-conjugated CD28 Antibody (CD28.2) is a Mouse-derived and PE conjugated monoclonal antibody, targeting to CD28.
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Host:
Mouse
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Isotype:
Mouse IgG1,κ
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Application:
FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Conjugation:
PE
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 5 ul per 106 cells in a 100 µl suspension |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.2) containing 0.1% Proclin300 and protein stabilizer.
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Storage & Stability
Stored at 2-8°C for 1 year, protect from light, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CD28, a cell surface glycoprotein receptor, predominantly expressed on activated T cells, belongs to the Ig superfamily and provides a critical co-stimulatory signal. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4. CD28 interacts with the CD80 dimer with relatively high affinity and the CD86 monomer with lower affinity, mediating T cell co-stimulation in conjunction with T cell receptor (TCR) signals. CD28 drives critical intracellular biochemical events including unique phosphorylation and transcriptional signaling, metabolism, and the production of key cytokines, chemokines, and survival signals that are essential for long-term expansion and differentiation of T cells. Most importantly, treatment of mice with a soluble CD28 antagonist induced antigen-specific tolerance that prevented the progression of autoimmune diseases and organ graft rejection.
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Expression
Tissue_specificity:Expressed in T-cells and plasma cells, but not in less mature B-cells -
Isoforms & Post-Translational Modification
CD28 has 7 isomers: P10747-1: 25066 Da (predicted); P10747-2: 11528 Da (predicted); P10747-3: 15369 Da (predicted); P10747-4: 14014 Da (predicted); P10747-5: 6099 Da (predicted); P10747-6: 8823 Da (predicted); P10747-7: 26186 Da (predicted).
Phosphorylated by LCK. Dephosphorylated by PTPN11;Tyrosine phosphorylated induced by CD40LG -
Subunit
Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2. Interacts with PIK3R1. Interacts with PRKCQ
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Synonyms
CD28,CD28-PE,CD28.2
Documentation
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