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PICALM Antibody (YA6703)

(Synonyms: CALM antibody; Clathrin assembly lymphoid myeloid leukemia antibody; Clathrin assembly lymphoid myeloid leukemia protein antibody; CLTH antibody; LAP antibody; Phosphatidylinositol-binding clathrin assembly protein antibody; PICAL_HUMAN antibody; PICALM antibody; )
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PICALM Antibody (YA6703) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PICALM.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • PICALM Antibody (YA6703) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:1000 1:50

Product Details

Description

PICALM Antibody (YA6703) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PICALM.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 65/71 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 71 kDa
Immunogen

Recombinant protein within human PICALM aa 1-450.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    PICALM is a Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF)[1][2][3][4][5][6][7][8][9].

  • Subcellular Localization

    Cell membrane,Membrane, clathrin-coated pit,Golgi apparatus,Cytoplasmic vesicle, clathrin-coated vesicle,Nucleus

  • Expression


    Tissue_Specificity: Expressed in all tissues examined

  • Isoforms & Post-Translational Modification

    Q13492 has 5 isomers: Q13492-1: 70755 Da (predicted); Q13492-2: 68764 Da (predicted); Q13492-3: 66393 Da (predicted); Q13492-4: 59918 Da (predicted); Q13492-5: 70037 Da (predicted).

  • Subunit

    Binds to clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity

  • SwissProt ID

    Q13492

  • Gene ID
    8301 [NCBI]
  • Synonyms

    CALM antibody; Clathrin assembly lymphoid myeloid leukemia antibody; Clathrin assembly lymphoid myeloid leukemia protein antibody; CLTH antibody; LAP antibody; Phosphatidylinositol-binding clathrin assembly protein antibody; PICAL_HUMAN antibody; PICALM antibody;

PICALM Antibody (YA6703) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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