PICK1 Antibody (YA1632)(PBS only)
(Synonyms: PICK 1; Pick1; PRKCABP)PICK1 Antibody (YA1632) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PICK1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:1000-1:5000 | 1:20-1:50 |
Product Details
PICK1 Antibody (YA1632) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PICK1.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 47 kDa
A synthetic peptide of human PICK1
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PICK1 is a Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
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Subcellular Localization
Cytoplasm, perinuclear region; Membrane; Peripheral membrane protein; Membrane; Lipid-anchor; Postsynaptic density; Synapse, synaptosome; Cytoplasm, cytoskeleton
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Expression
Tissue_specificity:Ubiquitous -
Isoforms & Post-Translational Modification
Q9NRD5 has 2 isomers: Q9NRD5-1: 46600 Da (predicted); Q9NRD5-2: 39808 Da (predicted).
Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors;Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD) -
Subunit
Monomer and homodimer. Interacts with CXADR.
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SwissProt ID
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Synonyms
PICK 1; Pick1; PRKCABP
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Research Field
Neuroscience
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