PITX3 Antibody
(Synonyms: PITX3, PTX3)PITX3 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PITX3.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS (pH 7.4), 0.05% NaN3, 40% Glycerol
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:50-100 |
Product Details
PITX3 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to PITX3.
-
Host Rabbit
-
Clonality polyclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 32 kDa;
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 32 kDa
Synthetic peptide of human PITX3
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS (pH 7.4), 0.05% NaN3, 40% Glycerol
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
PITX3 is a Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity)
-
Subcellular Localization
Nucleus
-
Expression
Tissue_Specificity: Highly expressed in developing eye lens. -
Isoforms & Post-Translational Modification
PITX3 has an amino acid length of 302, molecular weight is 31832 Da.PITX3 的氨基酸个数为 302 个，分子量为 31832 Da。
-
Subunit
Interacts with SFPQ
-
SwissProt ID
-
Synonyms
PITX3, PTX3
Documentation
Powered by Bioz
