PLIN5 Antibody (YA7909)(PBS only)
(Synonyms: LSDA5; LSDP5; MLDP; OXPAT)PLIN5 Antibody (YA7909) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PLIN5.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
PLIN5 Antibody (YA7909) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PLIN5.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 51.2 kDa
Human recombinant protein fragment corresponding to amino acids 1-463 of human PLIN5 produced in E.coli.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity)
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Subcellular Localization
Lipid droplet,Cytoplasm,Mitochondrion
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Expression
Tissue_Specificity: Expressed in skeletal muscle, liver, heart and kidney
Induction: Increased by endurance and sprint interval training -
Isoforms & Post-Translational Modification
Q00G26: 463 amino acids, molecular weight 50791 Da.
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Subunit
Homooligomer
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SwissProt ID
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Synonyms
LSDA5; LSDP5; MLDP; OXPAT
Documentation
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