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POLI Antibody (YA8056)(PBS only)

(Synonyms: RAD3OB; RAD30B)

POLI Antibody (YA8056) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to POLI.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • POLI Antibody (YA8056)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

POLI Antibody (YA8056) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to POLI.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 82.8 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 458-740 of human POLI produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    POLI is an Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity[1][2][3][4][5][6][7].

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_Specificity: Ubiquitous. Highly expressed in testis

  • Isoforms & Post-Translational Modification

    Q9UNA4: 740 amino acids, molecular weight 83006 Da.

  • Subunit

    Interacts with POLH (PubMed:12606586)

  • SwissProt ID

    Q9UNA4

  • Synonyms

    RAD3OB; RAD30B

POLI Antibody (YA8056)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • POLI Antibody (YA8056)(PBS only) Product Image