POT1 Antibody (YA1690)(PBS only)
(Synonyms: POT1; Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein)POT1 Antibody (YA1690) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to POT1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-1:5000 |
Product Details
POT1 Antibody (YA1690) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to POT1.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 71 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 71 kDa
A synthetic peptide of human POT1
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
POT1 component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity
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Subcellular Localization
Nucleus; Chromosome, telomere
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Expression
Tissue_specificity:Ubiquitous -
Isoforms & Post-Translational Modification
Q9NUX5 has 2 isomers: Q9NUX5-1: 71442 Da (predicted); Q9NUX5-2: 60534 Da (predicted).
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Subunit
Homodimer or homooligomer (PubMed:17237768). Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1 (PubMed:15316005, PubMed:15383534). Binds single-stranded telomeric DNA as a monomer (PubMed:15558049). Associated component of the telomerase holoenzyme complex (PubMed:19179534). Found in a complex with TERF1, TINF2 and TNKS1 (PubMed:12768206). Interacts with TNKS1. Forms heterodimers with ACD (PubMed:15231715, PubMed:27013236, PubMed:35420632). Identified in a complex with ACD and single-stranded telomeric DNA (PubMed:17237768)
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SwissProt ID
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Synonyms
POT1; Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein
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Research Field
Epigenetics and Nuclear Signaling
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