PPM1G Antibody (YA1698)
(Synonyms: Protein phosphatase 1G; PP2C-gamma; Protein phosphatase magnesium-dependent 1 gamma)PPM1G Antibody (YA1698) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PPM1G.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
PPM1G Antibody (YA1698) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PPM1G.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 59 kDa
Entrez Gene: 5496 Human ; 14208 Mouse ; 259229 Rat
SwissProt: O15355 Human ; Q61074 Mouse ;
OMIM: 605119 Human
Recombinant protein of human PPM1G
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PPM phosphatase family consists of at least 17 members. PPM phosphatases are dependent on Mg2+ or Mn2+ ions for their activity. PP1MG Protein, Human (His) forms a distinct holoenzyme complex with the PP2A regulatory subunit B56δ. B56δ promotes the re‐localization of PPM1G to the cytoplasm where the phosphatase can access a discrete set of substrates.α‐catenin, a component of adherens junction, as a new substrate for the PPM1G‐B56 phosphatase complex in the cytoplasm. B56δ‐PPM1G dephosphorylates α‐catenin at serine 641. Overexpression of PPM1G promotes the dephosphorylation of SRSF3 and changes the alternative splicing patterns of genes related to the cell cycle, the transcriptional regulation in HCC cells. The knockdown of PPM1G inhibited tumor growth in vivo.
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Subcellular Localization
Cytoplasm; Membrane; Lipid-anchor
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Expression
Tissue_specificity:Widely expressed. Most abundant in testis, skeletal muscle, and heart -
Subunit
Interacts with NOL3; may dephosphorylate NOL3
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SwissProt ID
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Synonyms
Protein phosphatase 1G; PP2C-gamma; Protein phosphatase magnesium-dependent 1 gamma
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Research Field
Cell Biology
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