2. Gene
  3. PPM1G - protein phosphatase, Mg2+/Mn2+ dependent 1G Gene

PPM1G - protein phosphatase, Mg2+/Mn2+ dependent 1G Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP2CG; PPP2CG; PP2CGAMMA

Gene ID: 5496 | Gene type: protein coding

About PPM1G

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,381,199-27,409,591 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 16 paralogues. Broad expression in testis (RPKM 133.0), lymph node (RPKM 28.8) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this Phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

PPM1G Products(1)

mRNA Protein Name
NM_177983.3 NP_817092.1 protein phosphatase 1G

PPM1G Protein Structure

PP2C

PP2C: Protein phosphatase 2C (27 - 107)

PP2C

PP2C: Protein phosphatase 2C (320 - 489)

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  • 546 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1G

PP2C-gamma

Recombinant PPM1G Proteins

Cat. No. Product Name Accession Purity
HY-P71022 PP1MG Protein, Human (His) O15355 (M317-D546) ≥95%

Related Diseases

Diseases Alias
Conduct Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10965 PPM1G Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PPM1G VGNC VGNC:76243
Canis familiaris PPM1G VGNC VGNC:44867
Mus musculus PPM1G MGD MGI:106065
Bos taurus PPM1G VGNC VGNC:33213
Rattus norvegicus PPM1G RGD RGD:628676
Felis catus PPM1G VGNC VGNC:68995
Others PPM1G NCBI