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PRDM10 Antibody (YA10078)

(Synonyms: RNF62; Probable E3 ubiquitin-protein ligase makorin-2; RING finger protein 62)

PRDM10 Antibody (YA10078) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to PRDM10.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.

  • Conjugation:
    Non-conjugated
  • PRDM10 Antibody (YA10078) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:1000-2000

Product Details

Description

PRDM10 Antibody (YA10078) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to PRDM10.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse
  • Observed Molecular Weight
    Observed band size: 190 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 130 kDa
Immunogen

Purified recombinant protein of human PRDM10.

Sensitivity

Endogenous

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    PRDM10 is a Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC[1].

  • Subcellular Localization

    Nucleus

  • Isoforms & Post-Translational Modification

    PRDM10 has 7 isoforms, Q9NQV6-3: amino acid length is 1147, molecular weight is 130136 Da (predicted); Q9NQV6-2: amino acid length is 1023, molecular weight is 116444 Da (predicted); Q9NQV6-1: amino acid length is 1061, molecular weight is 120711 Da (predicted); Q9NQV6-4: amino acid length is 1156, molecular weight is 130865 Da (predicted); Q9NQV6-5: amino acid length is 1074, molecular weight is 121924 Da (predicted); Q9NQV6-6: amino acid length is 1214, molecular weight is 137427 Da (predicted); Q9NQV6-7: amino acid length is 1160, molecular weight is 131349 Da (predicted).

  • SwissProt ID

    Q9NQV6

  • Gene ID
    56980 [NCBI]
  • Synonyms

    RNF62; Probable E3 ubiquitin-protein ligase makorin-2; RING finger protein 62

[1]. van de Beek I, et al. PRDM10 directs FLCN expression in a novel disorder overlapping with Birt-Hogg-Dubé syndrome and familial lipomatosis. Hum Mol Genet. 2023 Mar 20;32(7):1223-1235. [Content Brief]

PRDM10 Antibody (YA10078) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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