PRRX1 Antibody (YA7792)(PBS only)
(Synonyms: AGOTC; PHOX1; PMX1; PRX-1; PRX1)PRRX1 Antibody (YA7792) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PRRX1.
-
Host:
Mouse
-
Isotype:
IgG2b
-
Application:
WB, IHC-P
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|
| Dilution Ratio | 1:2000-3000 | 1:150-500 |
Product Details
PRRX1 Antibody (YA7792) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PRRX1.
-
Host Mouse
-
Species ReactivityHuman, Mouse, Rat
-
Calculated Molecular Weight Predicted band size: 27.1 kDa
Full length human recombinant protein of human PRRX1 produced in E.coli.
Affinity purified
Non-conjugated
IgG2b
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
PRRX1 is a Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process. Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. May play a role in homeostasis and regeneration of bone, white adipose tissue and derm|Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain|Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines[1].
-
Subcellular Localization
Nucleus
-
Expression
Tissue_Specificity: Widely expressed in embryonic and adult tissues, with highest levels in skeletal muscle. Isoform 1 is either expressed at similar or higher levels compared to isoform 2 in all embryonic tissues but skeletal muscle and heart. In adult tissues, expressed at lower levels compared to isoform 2|Widely expressed in embryonic and adult tissues, with highest levels in skeletal muscle. Isoform 2 is either expressed at similar or lower levels compared to isoform 1 in all embryonic tissues but skeletal muscle and heart, where it is expressed at higher levels. In adult tissues, expressed at higher levels compared to isoform 1 -
Isoforms & Post-Translational Modification
P54821 has two isomers: P54821-1: 27296 Da (predicted); P54821-2: 24396 Da (predicted).
-
Subunit
Interacts with SMAD3
-
SwissProt ID
-
Synonyms
AGOTC; PHOX1; PMX1; PRX-1; PRX1
Documentation
Powered by Bioz
