PSMC1 Antibody
(Synonyms: 26S proteasome regulatory subunit 4, P26s4, 26S proteasome AAA-ATPase subunit RPT2, Proteasome 26S subunit ATPase 1, PSMC1)PSMC1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to PSMC1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
PSMC1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to PSMC1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 58 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41; 49 kDa
Purified recombinant protein of human PSMC1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PSMC1 is a Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides
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Subcellular Localization
Cytoplasm; Nucleus; Membrane
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Isoforms & Post-Translational Modification
PSMC1 has 2 isoforms, P62191-1: amino acid length is 440, molecular weight is 49185 Da (predicted); P62191-2: amino acid length is 367, molecular weight is 41167 Da (predicted).PSMC1 存在 2 个异构体，P62191-1：氨基酸个数为 440 个，分子量为 49185 Da (预测)；P62191-2：氨基酸个数为 367 个，分子量为 41167 Da (预测)。
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Subunit
Component of the 19S proteasome regulatory particle complex.
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SwissProt ID
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Synonyms
26S proteasome regulatory subunit 4, P26s4, 26S proteasome AAA-ATPase subunit RPT2, Proteasome 26S subunit ATPase 1, PSMC1
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