PTEN Antibody (YA6432)
(Synonyms: ITGA 2; MGC11227; MHAM; MMAC 1; MMAC1; Bannayan Zonana; BZS a; Multiple hamartoma(Cowden syndrome); Mutated in Mutiple Advanced Cancers 1; Phosphatase and Tensin Homolog; Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN; Phosphatidylinositol 345 trisphosphate 3 phosphatase; Platelet antigen BR; PTEN 1; PTEN1; Tensin homolog; TEP 1; TEP1; VLA 2 Receptor alpha Subunit.)
Based on 1 Customer Validation
PTEN Antibody (YA6432) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PTEN.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, IHC-F, ICC/IF, IF-Tissue
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|---|
| Dilution Ratio | 1:100-500 | 1:100-500 | 1:100-200 | 1:100-500 |
Product Details
PTEN Antibody (YA6432) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PTEN.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 44 kDa
KLH conjugated synthetic peptide derived from human PTEN
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PTEN (Phosphatase and tensin homologue deleted on chromosome 10), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes. PTEN has a much wider active site cleft enabling it to bind the PtdIns (3, 4, 5) P3 substrate. a highly potent and specific inhibitor of PTEN that increases cellular PtdIns (3, 4, 5) P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations.
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Subcellular Localization
Cytoplasm,Nucleus,Nucleus, PML body,Cell projection, dendritic spine,Postsynaptic density,Secreted
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Expression
Tissue_Specificity: Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas
Induction: Down-regulated by TGFB1 -
Isoforms & Post-Translational Modification
P60484 has three isomers: P60484-1: 47166 Da (predicted); P60484-2: 64882 Da (predicted); P60484-3: 19796 Da (predicted).
Constitutively phosphorylated by CK2 under normal conditions丨Monoubiquitinated; monoubiquitination is increased in presence of retinoic acid丨Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation丨ISGylated -
Subunit
Monomer
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SwissProt ID
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Synonyms
ITGA 2; MGC11227; MHAM; MMAC 1; MMAC1; Bannayan Zonana; BZS a; Multiple hamartoma(Cowden syndrome); Mutated in Mutiple Advanced Cancers 1; Phosphatase and Tensin Homolog; Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN; Phosphatidylinositol 345 trisphosphate 3 phosphatase; Platelet antigen BR; PTEN 1; PTEN1; Tensin homolog; TEP 1; TEP1; VLA 2 Receptor alpha Subunit.
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