PTPN22 Antibody (YA8394)
(Synonyms: LYP; LYP1; LYP2; PEP; PTPN8)PTPN22 Antibody (YA8394) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PTPN22.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:800-1500 |
Product Details
PTPN22 Antibody (YA8394) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PTPN22.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 91.5 kDa
Human recombinant protein fragment corresponding to amino acids 359-449 of human PTPN22 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PTPN22 acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon. Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy. Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3. Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide)[1][2][3][4][5][6].
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells
Induction: By muramyl-dipeptide and lipopolysaccharide -
Isoforms & Post-Translational Modification
Q9Y2R2 has 6 isomers: Q9Y2R2-1: 91705 Da (predicted); Q9Y2R2-2: 78769 Da (predicted); Q9Y2R2-3: 85138 Da (predicted); Q9Y2R2-4: 88647 Da (predicted); Q9Y2R2-5: 20932 Da (predicted); Q9Y2R2-6: 75488 Da (predicted).
Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases -
Subunit
Interacts with CSK (PubMed:15208781)
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SwissProt ID
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Synonyms
LYP; LYP1; LYP2; PEP; PTPN8
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