RAB3IP Antibody (YA8761)(PBS only)

Cat. No.: HY-P89077A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

RAB3IP Antibody (YA8761) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAB3IP.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

RAB3IP Antibody (YA8761) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAB3IP.

Host

Mouse

Molecular Weight

Predicted band size: 51.1 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q96QF0

Immunogen

Full length human recombinant protein of human RAB3IP produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879, PubMed:31204173)

Subcellular Localization：Cytoplasm,Nucleus,Cytoplasm, cytoskeleton,Cell projection, lamellipodium,Vesicle,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Expression：
Tissue_Specificity: Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver

Isoforms & Post-Translational Modification：Q96QF0 has 8 isomers: Q96QF0-1: 53021 Da (predicted); Q96QF0-2: 51250 Da (predicted); Q96QF0-3: 43446 Da (predicted); Q96QF0-4: 45217 Da (predicted); Q96QF0-5: 33234 Da (predicted); Q96QF0-6: 35005 Da (predicted); Q96QF0-7: 34270 Da (predicted); Q96QF0-8: 28642 Da (predicted).
Phosphorylated by AKT1; the phosphorylation alters its GEF activity

Subunit：Homodimer (PubMed:26258637)

Synonyms

RABIN3; RABIN8

Documentation

User Guide for Antibodies (1077 KB)