Copy Link Print Information

RAB3IP Antibody (YA8761)(PBS only)

(Synonyms: RABIN3; RABIN8)

RAB3IP Antibody (YA8761) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAB3IP.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • RAB3IP Antibody (YA8761)(PBS only) Product Image
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download
Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

RAB3IP Antibody (YA8761) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAB3IP.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 51.1 kDa
Immunogen

Full length human recombinant protein of human RAB3IP produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    RAB3IP is a Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation[1][2][3][4][5][6].

  • Subcellular Localization

    Cytoplasm,Nucleus,Cytoplasm, cytoskeleton,Cell projection, lamellipodium,Vesicle,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

  • Expression


    Tissue_Specificity: Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver

  • Isoforms & Post-Translational Modification

    Q96QF0 has 8 isomers: Q96QF0-1: 53021 Da (predicted); Q96QF0-2: 51250 Da (predicted); Q96QF0-3: 43446 Da (predicted); Q96QF0-4: 45217 Da (predicted); Q96QF0-5: 33234 Da (predicted); Q96QF0-6: 35005 Da (predicted); Q96QF0-7: 34270 Da (predicted); Q96QF0-8: 28642 Da (predicted).
    Phosphorylated by AKT1; the phosphorylation alters its GEF activity

  • Subunit

    Homodimer (PubMed:26258637)

  • SwissProt ID

    Q96QF0

  • Synonyms

    RABIN3; RABIN8

RAB3IP Antibody (YA8761)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • RAB3IP Antibody (YA8761)(PBS only) Product Image
    1/16
  • RAB3IP Antibody (YA8761)(PBS only) Product Image