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RANBP1 Antibody (YA7799)(PBS only)

(Synonyms: HTF9A)

RANBP1 Antibody (YA7799) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to RANBP1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    WB

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • RANBP1 Antibody (YA7799)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-2000

Product Details

Description

RANBP1 Antibody (YA7799) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to RANBP1.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
Immunogen

Full length human recombinant protein of human RANBP1 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2b

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    RANBP1 plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP[1][2][3][4].

  • Isoforms & Post-Translational Modification

    P43487 has two isomers: P43487-1: 23310 Da (predicted); P43487-2: 23239 Da (predicted).

  • Subunit

    Interacts with RAN (via C-terminus of GTP-bound form) but not with GDP-bound RAN (PubMed:7882974, PubMed:7891706, PubMed:8896452)

  • SwissProt ID

    P43487

  • Synonyms

    HTF9A

RANBP1 Antibody (YA7799)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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    1/16
  • RANBP1 Antibody (YA7799)(PBS only) Product Image