RASSF1A Antibody (YA7255)
(Synonyms: RDA32, RASSF1, Ras association domain-containing protein 1)
Based on 1 Customer Validation
RASSF1A Antibody (YA7255) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RASSF1A.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P, IHC-F, IF-Tissue
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Reactivity :
Human
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|
| Dilution Ratio | 1:50-200 | 1:50-200 | 1:50-200 |
Product Details
RASSF1A Antibody (YA7255) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RASSF1A.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 39 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 39 kDa
A synthesized peptide derived from human RASSF1: 300-344/344.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RASSF1A is a Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage
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Subcellular Localization
Cytoplasm, cytoskeleton,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,Cytoplasm, cytoskeleton, spindle,Cytoplasm, cytoskeleton, spindle pole,Nucleus,Nucleus
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Expression
Tissue_Specificity: Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells -
Isoforms & Post-Translational Modification
Q9NS23 has 8 isomers: Q9NS23-1: 39219 Da (predicted); Q9NS23-2: 38814 Da (predicted); Q9NS23-3: 21899 Da (predicted); Q9NS23-4: 31226 Da (predicted); Q9NS23-5: 39265 Da (predicted); Q9NS23-6: 9937 Da (predicted); Q9NS23-7: 16120 Da (predicted); Q9NS23-9: 8656 Da (predicted).
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Subunit
Interacts with MAP1S (PubMed:15205320, PubMed:15753381)
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SwissProt ID
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Synonyms
RDA32, RASSF1, Ras association domain-containing protein 1
Documentation
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