RBM15B Antibody (YA7061)
(Synonyms: 1810017N16Rik antibody; Chromosome 3p21.1 gene sequence antibody; HUMAGCGB antibody; huOTT3 antibody; One twenty two protein 3 antibody; One-twenty two protein 3 antibody; OTT3 antibody; Putative RNA binding protein 15B antibody; Putative RNA-binding protein 15B antibody; RB15B_HUMAN antibody)RBM15B Antibody (YA7061) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RBM15B.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:2000 |
Product Details
RBM15B Antibody (YA7061) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RBM15B.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 97 kDa
Recombinant protein within human RBM15B aa 1-200 / 890.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RBM15B is a RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1[1][2][3][4].
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Subcellular Localization
Nucleus, nucleoplasm,Nucleus speckle,Nucleus envelope
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Expression
Tissue_Specificity: Ubiquitously expressed -
Isoforms & Post-Translational Modification
Q8NDT2 has two isomers: Q8NDT2-1: 97205 Da (predicted); Q8NDT2-2: 63156 Da (predicted).
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Subunit
Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:27602518)
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SwissProt ID
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Synonyms
1810017N16Rik antibody; Chromosome 3p21.1 gene sequence antibody; HUMAGCGB antibody; huOTT3 antibody; One twenty two protein 3 antibody; One-twenty two protein 3 antibody; OTT3 antibody; Putative RNA binding protein 15B antibody; Putative RNA-binding protein 15B antibody; RB15B_HUMAN antibody
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