Reelin Antibody (YA3340)

Cat. No.: HY-P83595: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Reelin Antibody (YA3340) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Reelin.

For research use only. We do not sell to patients.

Size	Stock	Quantity
Free Sample	Apply now
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Reelin Antibody (YA3340) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Reelin Antibody (YA3340) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Reelin.

Host

Rabbit

Clonality

Recombinant, Monoclonal

Molecular Weight

Predicted band size: 388 kDa;

Observed band size: 388 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

P78509

Gene ID

5649 [NCBI]

Immunogen

A synthesized peptide derived from human Reelin aa3240-3300/3460.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	Purity	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion

Subcellular Localization：Secreted, extracellular space, extracellular matrix

Expression：
Tissue_specificity:Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In human brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% with schizophrenia. Also expressed in human liver

Isoforms & Post-Translational Modification：P78509 has 3 isomers: P78509-1: 388388 Da (predicted); P78509-2: 388201 Da (predicted); P78509-3: 384093 Da (predicted).
N-glycosylated and to a lesser extent also O-glycosylated

Subunit：Oligomer of disulfide-linked homodimers

RRID

AB_3105703

Database

Entrez Gene: 5649 Human ; 19699 Mouse ; 24718 Rat

SwissProt: P78509 Human ; Q60841 Mouse ; P58751 Rat

OMIM: 257320 Human

Research Field

Neuroscience

Synonyms

LIS2; PRO1598; Reeler; Reelin; RELN; RL

Documentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

Reelin Antibody (YA3340) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Reelin Antibody (YA3340)

Reelin Antibody (YA3340) Featured Recommendations:

Product Detail

Background

Documentation

Reelin Antibody (YA3340) Related Classifications

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