RLIM Antibody (YA8831)
(Synonyms: NY-REN-43; RNF12)RLIM Antibody (YA8831) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RLIM.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
RLIM Antibody (YA8831) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RLIM.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
Full length human recombinant protein of human RLIM produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RLIM is an E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Expressed in many tissues -
Isoforms & Post-Translational Modification
Q9NVW2 has two isomers: Q9NVW2-1: 68549 Da (predicted); Q9NVW2-2: 52638 Da (predicted).
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Subunit
Interacts with LIM/homeobox factors such as LHX3
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SwissProt ID
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Synonyms
NY-REN-43; RNF12
Documentation
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