ROS1 Antibody (YA7703)

Cat. No.: HY-P88018: Ficha de datos User Guide for Antibodies
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ROS1 Antibody (YA7703) is a Mouse-derived and non-conjugated IgG1, monoclonal antibody, targeting to ROS1.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

ROS1 Antibody (YA7703) is a Mouse-derived and non-conjugated IgG1, monoclonal antibody, targeting to ROS1.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 258 kDa;

Species Reactivity

Human

SwissProt ID

P08922

Immunogen

Recombinant human ROS1.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:100-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-500

Sensitivity	Endogenous	Pureza	affinity purified by Protein G
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Solution

Formulation

Supplied in 10mM PBS with 0.09% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2

Subcellular Localization：Cell membrane

Expression：
Tissue_Specificity: Expressed in brain. Expression is increased in primary gliomas

Isoforms & Post-Translational Modification：P08922: 2347 amino acids, molecular weight 263915 Da.

Subunit：Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By similarity)

Synonyms

MCF3, ROS, ROS1, Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase

Documentación

User Guide for Antibodies (1077 KB)