RSPO3 Antibody (YA7994)

製品番号: HY-P88310: データシート User Guide for Antibodies
FAQs
Technical Support

RSPO3 Antibody (YA7994) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RSPO3.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量	価格（税別）	在庫状況
20 μL	$115	見積もりとリードタイムを求めるのご確認
50 μL	$185	見積もりとリードタイムを求めるのご確認
100 μL	$300	見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

RSPO3 Antibody (YA7994) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RSPO3.

Host

Mouse

Clonality

Monoclonal

分子量

Predicted band size: 30.7 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9BXY4

Immunogen

Human recombinant protein fragment corresponding to amino acids 22-272 of human RSPO3 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	純度	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720)

Subcellular Localization：Secreted

Expression：
Tissue_Specificity: Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node (PubMed:12463421). Highly expressed in endothelial cells (PubMed:26766444)

Isoforms & Post-Translational Modification：Q9BXY4 has two isomers: Q9BXY4-1: 30929 Da (predicted); Q9BXY4-2: 33233 Da (predicted).

Subunit：Interacts with the extracellular domain of FZD8 and LRP6 (By similarity)

Synonyms

CRISTIN1; PWTSR; THSD2

ドキュメンテーション

User Guide for Antibodies (1077 KB)

RSPO3 Antibody (YA7994) 関連分類

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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RSPO3 Antibody (YA7994)

Product Detail

Background

説明

RSPO3 Antibody (YA7994) 関連分類

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