S100A11 Antibody
(Synonyms: S100 calcium binding protein A11; MLN70; S100C; HEL-S-43)S100A11 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to S100A11.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
S100A11 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to S100A11.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 12 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 12 kDa
Synthetic peptide corresponding to Human S100A11.The exact sequence is proprietary to MCE.
Endogenous
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
S100A11 is a calcium-binding S100 protein that mediates Ca2+-dependent growth control in human keratinocytes through phosphorylation, nucleolin binding, nuclear translocation, and activation of p21^CIP1/WAF1[1]. Mechanistically, S100A11 also supports plasma membrane repair and survival of invasive cancer cells, linking calcium signaling to membrane stress adaptation[2]. In osteoarthritis models, extracellular S100A11 acts through RAGE-p38 MAPK signaling to drive chondrocyte hypertrophy and cartilage matrix catabolism[2]. In hepatocellular carcinoma, S100A11 promotes migration and invasion through AKT and ERK signaling pathways[3]. Compared with many S100 isoforms, S100A11 shows selective extracellular cytokine binding because only S100A11, S100A12, and S100A13 interacted with soluble TNF among eighteen tested S100 proteins[4]. For experimental inhibition studies, tranilast blocked the interaction between S100A11 and the RAGE V domain and reduced cell proliferation[5].
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Subcellular Localization
Cytoplasm; Nucleus
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Subunit
Homodimer; disulfide-linked
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SwissProt ID
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Synonyms
S100 calcium binding protein A11; MLN70; S100C; HEL-S-43
Documentation
[1]. Sakaguchi M, et al. S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes. J Cell Biol. 2003 Nov 24;163(4):825-35. [Content Brief]
[2]. Jaiswal JK, et al. S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells. Nat Commun. 2014 May 8;5:3795. [Content Brief]
[3]. Zheng M, et al. S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma. Int J Med Sci. 2023 Jan 31;20(3):318-328. [Content Brief]
[4]. Kazakov AS, et al. Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its Activity. Int J Mol Sci. 2022 Dec 15;23(24):15956. [Content Brief]
[5]. Huang YK, et al. Tranilast Blocks the Interaction between the Protein S100A11 and Receptor for Advanced Glycation End Products (RAGE) V Domain and Inhibits Cell Proliferation. J Biol Chem. 2016 Jul 1;291(27):14300-14310. [Content Brief]
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