S100A11 - S100 calcium binding protein A11 Gene

Also Known as MLN70; S100C; HEL-S-43

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6282

About S100A11

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,032,506-152,037,004 (from NCBI)

This gene has 2 transcripts (splice variants), 293 orthologues and 21 paralogues. Broad expression in esophagus (RPKM 707.5), placenta (RPKM 273.6) and 20 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]

S100A11 Products (1)

mRNA Protein Name
NM_005620.2 NP_005611.1 protein S100-A11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables S100 protein binding IPI
IPI: Inferred from physical interaction
10913138 GOA
enables calcium-dependent protein binding IDA
IDA: Inferred from direct assay
10913138 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10913138 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10913138 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
21139050 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10913138 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10913138 GOA
located in ruffle IDA
IDA: Inferred from direct assay
10913138 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A11 Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (10 - 53)

EF-hand_1

EF-hand_1: EF hand (60 - 84)

  • 0
  • 100
  • 105 a.a.
Protein Preferred Names Protein Names

protein S100-A11

  • MLN 70

S100A11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
S100A11 P31949 TRPM4 Homo sapiens Q8TD43
FPS
31837246
Intra
S100A11 P31949 TNF Homo sapiens P01375
Crosslink
36555597
Intra
S100A11 P31949 TP53 Homo sapiens P04637
FPS
31837246
Intra
S100A11 P31949 S100B Homo sapiens P04271
Y2H
10913138
Intra
S100A11 P31949 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A11 Proteins

Cat. No. Product Name Accession Purity
HY-P72482 S100A11 Protein, Human P31949 (M1-T105) ≥ 95%, as determined by reducing SDS-PAGE.

S100A11 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80944 S100A11 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Trachea Leiomyoma

  • Tracheal Neoplasms

  • Leiomyoma Of The Trachea

  • Tracheal Neoplasm

  • Tracheal Leiomyoma
Clear Cell Sarcoma

  • Sarcoma, Clear Cell

  • Adult Soft Part Clear Cell Sarcoma

  • Clear Cell Sarcoma Of Soft Parts

  • Malignant Melanoma Of Soft Parts

  • Malignant Melanoma Of Soft Tissues

  • Melanoma, Malignant, Of Soft Parts

  • Sarcoma Clear Cell
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12373 S100A11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17154 S100a11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23604 S100a11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris S100A11 VGNC VGNC:54355
Rattus norvegicus S100A11 RGD RGD:1303295
Mus musculus S100A11 MGD MGI:1338798
Bos taurus S100A11 VGNC VGNC:34238
Others S100A11 NCBI