SAP97 Antibody (YA2731)
(Synonyms: DLG1; DLGH1; hDlg; SAP97)SAP97 Antibody (YA2731) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAP97.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
SAP97 Antibody (YA2731) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAP97.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 140 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 100 kDa
Entrez Gene: 1739 Human ; 13383 Mouse ; 25252 Rat
SwissProt: Q12959 Human ; Q811D0 Mouse ; Q62696 Rat
OMIM: 601014 Human
A synthesized peptide derived from human SAP97 aa1-44/904.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SAP97 is essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion. May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane[1].
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Subcellular Localization
Cell membrane; Peripheral membrane protein; Basolateral cell membrane; Endoplasmic reticulum membrane; Postsynaptic density; Synapse; Cell membrane, sarcolemma; Apical cell membrane; Cell junction; Cytoplasm
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Expression
Tissue_specificity:Abundantly expressed in atrial myocardium (at protein level) . Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level) . Expressed in the brain (at protein level) (PubMed:23676497) . Widely expressed, with isoforms displaying different expression profiles -
Isoforms & Post-Translational Modification
Q12959 has 9 isomers: Q12959-1: 100455 Da (predicted); Q12959-2: 103321 Da (predicted); Q12959-3: 97076 Da (predicted); Q12959-4: 99942 Da (predicted); Q12959-5: 95166 Da (predicted); Q12959-6: 99090 Da (predicted); Q12959-7: 101849 Da (predicted); Q12959-8: 87248 Da (predicted); Q12959-9: 88485 Da (predicted).
Phosphorylated by MAPK12 (PubMed:20605917). Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity);Ubiquitinated; by MARCHF2 which results in its degradation -
Subunit
Homotetramer (Probable). Interacts (via guanylate kinase-like domain) with KIF13B (PubMed:10859302).
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SwissProt ID
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Synonyms
DLG1; DLGH1; hDlg; SAP97
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Research Field
Neuroscience
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