2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. SAP97 Antibody (YA2731)

SAP97 Antibody (YA2731)

Cat. No.: HY-P82986
User Guide for Antibodies Technical Support

SAP97 Antibody (YA2731) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAP97.

For research use only. We do not sell to patients.

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20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

SAP97 Antibody (YA2731) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAP97.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 100 kDa;
Observed band size: 140 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human SAP97 aa1-44/904.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497)
Subcellular Localization：Cell membrane; Peripheral membrane protein; Basolateral cell membrane; Endoplasmic reticulum membrane; Postsynaptic density; Synapse; Cell membrane, sarcolemma; Apical cell membrane; Cell junction; Cytoplasm
Expression：
Tissue_specificity:Abundantly expressed in atrial myocardium (at protein level) . Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level) . Expressed in the brain (at protein level) (PubMed:23676497) . Widely expressed, with isoforms displaying different expression profiles
Isoforms & Post-Translational Modification：Q12959 has 9 isomers: Q12959-1: 100455 Da (predicted); Q12959-2: 103321 Da (predicted); Q12959-3: 97076 Da (predicted); Q12959-4: 99942 Da (predicted); Q12959-5: 95166 Da (predicted); Q12959-6: 99090 Da (predicted); Q12959-7: 101849 Da (predicted); Q12959-8: 87248 Da (predicted); Q12959-9: 88485 Da (predicted).
Phosphorylated by MAPK12 (PubMed:20605917). Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity);Ubiquitinated; by MARCHF2 which results in its degradation
Subunit：Homotetramer (Probable). Interacts (via guanylate kinase-like domain) with KIF13B (PubMed:10859302).
Database

Entrez Gene: 1739 Human ; 13383 Mouse ; 25252 Rat

SwissProt: Q12959 Human ; Q811D0 Mouse ; Q62696 Rat

OMIM: 601014 Human

Research Field

Neuroscience
Synonyms
DLG1; DLGH1; hDlg; SAP97
Documentation
User Guide for Antibodies (1077 KB)

SAP97 Antibody (YA2731) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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