2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. SARA Antibody (YA3226)

SARA Antibody (YA3226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SARA.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

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  • Descripciòn

  • Referencias

Descripciòn

SARA Antibody (YA3226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SARA.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Peso molecular
Predicted band size: 156 kDa;
Observed band size: 156 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Rat
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human SARA
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:2000-1:5000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
Sensitivity Endogenous Pureza Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Background
Function：Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization
Subcellular Localization：Cytoplasm; Early endosome membrane
Expression：
Tissue_specificity:Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes
Isoforms & Post-Translational Modification：O95405 has 3 isomers: O95405-1: 156403 Da (predicted); O95405-2: 150348 Da (predicted); O95405-3: 83721 Da (predicted).
Subunit：Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation. Interacts with SMAD3. Interacts with TGFBR1 and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor. Interacts with PML
Database

Entrez Gene: 9372 Human

SwissProt: O95405 Human

OMIM: 603755 Human

Research Field

Signal Transduction
Synonyms
NSP; SARA; MADHIP; SMADIP; PPP1R173
Documentación
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)
Referencias

SARA Antibody (YA3226) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

Nombre del producto:
SARA Antibody (YA3226)
Cat. No.:
HY-P83481
Cantidad:
MCE Japan Authorized Agent:

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Observaciones

SAFETY DATA SHEET (SDS)

English - EN (251 KB)

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