Sarcomeric alpha Actinin Antibody (YA1903)
(Synonyms: Actin binding protein; Actinin alpha 2; ACTN2; Alpha actinin 2; CMD1AA)Sarcomeric alpha Actinin Antibody (YA1903) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sarcomeric alpha Actinin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:20 |
Product Details
Sarcomeric alpha Actinin Antibody (YA1903) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sarcomeric alpha Actinin.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 104 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 104 kDa
Entrez Gene: 88 Human ; 11472 Mouse ; 291245 Rat
SwissProt: P35609 Human ; Q9JI91 Mouse ;
OMIM: 612158 Human
A synthetic peptide of human Sarcomeric Alpha Actinin aa1-14.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Sarcomeric alpha Actinin is a F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein
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Subcellular Localization
Cytoplasm, myofibril, sarcomere, Z line
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Expression
Tissue_specificity:It is expressed in both skeletal muscle and cardiac muscle. -
Isoforms & Post-Translational Modification
P35609 has 2 isomers: P35609-1: 103854 Da (predicted); P35609-2: 103920 Da (predicted).
Ubiquitinated by FBXL22, leading to proteasomal degradation -
Subunit
Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST isoform 1 (via N-terminus). Interacts with PARVB. Interacts with SYNPO2
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SwissProt ID
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Synonyms
Actin binding protein; Actinin alpha 2; ACTN2; Alpha actinin 2; CMD1AA
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Research Field
Signal Transduction
Documentation
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