SF3A1 Antibody (YA8078)
(Synonyms: PRP21; PRPF21; SAP114; SF3A120)SF3A1 Antibody (YA8078) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SF3A1.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-4000 | 1:500-800 |
Product Details
SF3A1 Antibody (YA8078) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SF3A1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 88.7 kDa
Human recombinant protein fragment corresponding to amino acids 249-568 of human SF3A1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SF3A1 component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes[1][2][3][4][5].
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Subcellular Localization
Nucleus,Nucleus speckle
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Expression
Tissue_Specificity: Ubiquitously expressed -
Isoforms & Post-Translational Modification
Q15459 has two isomers: Q15459-1: 88886 Da (predicted); Q15459-2: 81678 Da (predicted).
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Subunit
Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:32494006, PubMed:36797247)
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SwissProt ID
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Synonyms
PRP21; PRPF21; SAP114; SF3A120
Documentation
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