SGK196 Antibody (YA8707)
(Synonyms: MDDGA12; MDDGC12; SGK196)SGK196 Antibody (YA8707) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SGK196.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
SGK196 Antibody (YA8707) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SGK196.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 39.9 kDa
Human recombinant protein fragment corresponding to amino acids 141-350 of human SGK196 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SGK196 is a Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Highest expression is observed in brain, skeletal muscle, kidney and heart in fetal and adult tissues -
Isoforms & Post-Translational Modification
Q9H5K3: 350 amino acids, molecular weight 40050 Da.
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SwissProt ID
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Synonyms
MDDGA12; MDDGC12; SGK196
Documentation
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