SH3BP1 Antibody (YA8375)
(Synonyms: ARHGAP43)SH3BP1 Antibody (YA8375) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SH3BP1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
SH3BP1 Antibody (YA8375) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SH3BP1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 75.5 kDa
Full length human recombinant protein of human SH3BP1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SH3BP1 is a GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells[1][2][3][4].
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Subcellular Localization
Cell projection,Cell junction, tight junction,Cell junction, adherens junction,Cell projection, phagocytic cup,Nucleus,Cytoplasm, cytosol
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Isoforms & Post-Translational Modification
Q9Y3L3 has four isomers: Q9Y3L3-1: 75713 Da (predicted); Q9Y3L3-2: 50820 Da (predicted); Q6ZT62-1: 73599 Da (predicted); Q6ZT62-2: 66180 Da (predicted).
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Subunit
Interacts with RAC1 (By similarity)
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SwissProt ID
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Synonyms
ARHGAP43
Documentation
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