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SLC12A1 Antibody (YA1403)

(Synonyms: BSC1; NKCC2)

SLC12A1 Antibody (YA1403) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC12A1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

SLC12A1 Antibody (YA1403) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC12A1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 150 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 121 kDa
Species Reactivity Database

Entrez Gene: 6557 Human

SwissProt: Q13621 Human

Immunogen

Recombinant protein of human NKCC2

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    SLC12A1 is a Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system[1].

  • Subcellular Localization

    Apical cell membrane; Multi-pass membrane protein

  • Expression


    Tissue_specificity:Kidney; located in the thick ascending limb of the renal tubule (protein level) .

  • Isoforms & Post-Translational Modification

    Q13621 has 3 isomers: Q13621-1: 121450 Da (predicted); Q13621-2: Da (predicted); Q13621-3: 121388 Da (predicted).
    Phosphorylated at Ser-91, Thr-100 and Thr-105 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), promoting its activity

  • Subunit

    When phosphorylated, interacts with PPP3CB

  • SwissProt ID

    Q13621

  • Gene ID
    6557 [NCBI]
  • Synonyms

    BSC1; NKCC2

  • Research Field

    Signal Transduction

References

[1]. Richardson C, et al. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci. 2011 Mar 1;124(Pt 5):789-800. [Content Brief]

SLC12A1 Antibody (YA1403) Related Classifications

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Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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