SLC22A17 Antibody (YA8306)(PBS only)

Cat. No.: HY-P88622A: Data Sheet User Guide for Antibodies
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SLC22A17 Antibody (YA8306) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A17.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명
References

제품 설명

SLC22A17 Antibody (YA8306) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A17.

Host

Mouse

분자량

Predicted band size: 55.5 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q8WUG5

Immunogen

Human recombinant protein fragment corresponding to amino acids 241-300 of human SLC22A17 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-800

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity)

Subcellular Localization：Cell membrane,Vacuole membrane

Expression：
Tissue_Specificity: Expressed in brain
Induction: Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway

Isoforms & Post-Translational Modification：Q8WUG5 has three isomers: Q8WUG5-1: 68619 Da (predicted); Q8WUG5-2: 66590 Da (predicted); Q8WUG5-3: 32644 Da (predicted).

Synonyms

24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3

각종 서류

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/vero-c1008-cell.html