SLC22A17 Antibody (YA8306)(PBS only)
(Synonyms: 24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3)SLC22A17 Antibody (YA8306) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A17.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
IHC-P
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
SLC22A17 Antibody (YA8306) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC22A17.
-
Host Mouse
-
Species ReactivityHuman, Mouse, Rat
-
Calculated Molecular Weight Predicted band size: 55.5 kDa
Human recombinant protein fragment corresponding to amino acids 241-300 of human SLC22A17 produced in E.coli.
Affinity purified
Non-conjugated
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
SLC22A17 cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis
-
Subcellular Localization
Cell membrane,Vacuole membrane
-
Expression
Tissue_Specificity: Expressed in brain
Induction: Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway -
Isoforms & Post-Translational Modification
Q8WUG5 has three isomers: Q8WUG5-1: 68619 Da (predicted); Q8WUG5-2: 66590 Da (predicted); Q8WUG5-3: 32644 Da (predicted).
-
SwissProt ID
-
Synonyms
24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3
Documentation
Powered by Bioz
